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Akamatsu, Ken
no journal, ,
We have developed a thermal-neutron-sensitive liposome ruptured by thermal neutron irradiation, aiming to construct a release control system which the incorporated anticancer agents in liposomes accumulated at tumor can be released following to destruction of them by thermal neutron irradiation. We predict that one of most effective chemical species injuring liposome is hydroxyl radical produced by radiolysis of water. According to the hypothesis, as the first step of the development, we have investigated the relationship between lipid compositions in liposome (a 3-membered system: cholesterol, a saturated phospholipid, and an unsaturated phospholipid) and radiation sensitivity, using a soft X-ray equipment (Softex M-150WE). Based on the results from the X-ray experiments, a liposome with both a boron compound and anticancer agent was prepared, and the ability of controlled release by thermal neutron irradiation (JRR4, JAEA).
Kumada, Hiroaki; Nakamura, Takemi; Ono, Koji*; Maruhashi, Akira*; Matsumura, Akira*
no journal, ,
no abstracts in English
Tahara, Yoshihisa*; Abe, Shinji*; Sasa, Toshinobu; Yonai, Shunsuke*; Baba, Mamoru*; Yokobori, Hitoshi*
no journal, ,
Conceptual study of the epithermal neutron source for BNCT by the bomberdment of 400 MeV proton which is planned to supply at Japan proton accelerator research complex, J-PARC. The neutron source, which has two neutron extraction port, is designed to obtain epithermal neutron source by the moderation of spallation neutron source from tungsten target using iron and fluental moderator. By the analytical result of the radiation dose in human phantom located at the exit of exposure port, about 60 minutes of irradiation time is obtained by the injection of 5 micro ampere protons. It is shown that this spallation neutron source is applicable to the epithermal neutron source for BNCT.
Iwamoto, Yosuke; Matsuda, Norihiro; Sakamoto, Yukio; Ochiai, Kentaro; Nakane, Yoshihiro; Nakashima, Hiroshi; Shibata, Tokushi
no journal, ,
no abstracts in English
Yanagie, Hironobu*; Sakurai, Yoshinori*; Kumada, Hiroaki; Naka, Hideji*; Furuya, Yoshitaka*; Takamoto, Shinichi*; Ono, Koji*; Takahashi, Hiroyuki*
no journal, ,
no abstracts in English